ESPL1/Separase. an endopeptidase. is required for centrosome duplication and separation of sister-chromatides in anaphase of mitosis. Overexpression and deregulated proteolytic activity of Separase as frequently observed in human cancers is associated with the occurrence of supernumerary centrosomes. https://parisnaturalfoodes.shop/product-category/rxomega-3-factors/